Thesecond season ofPrison Break, an American serial drama television series, commenced airing in the United States on August 21, 2006 on Mondays at 9:00 pm ( EST ) on the Fox Broadcasting Company .Prison Breakis produced by Adelstein-Parouse Productions, in association with Rat Television, Original Television Movie and 20th Century Fox Television . The season contains 22 episodes, and concluded on April 2, 2007. Series creator Paul Scheuring describes the second season as "The Fugitivetimes eight", and likens it to the "second half ofThe Great Escape".

Prison Breakrevolves around two brothers: one who has been sentenced to death for a crime he did not commit and his younger sibling, a genius who devises an elaborate plan to help him escape prison. The brothers, along with six other prisoners at Fox River State Penitentiary , manage to escape, and the second season follows a massive manhunt chasing the group.Dubbed the Fox River Eight , the group splits and members go their individual way, occasionally meeting up to help each other. They struggle to escape from the police while avoiding a secret group of multinationals called The Company , that wants them all dead.

For the season, three characters are downgraded from series regular to recurring status, and a new character is introduced. Filming took place in Dallas, Texas due to a close proximity of rural and urban settings. For the final three episodes, scenes were filmed in Pensacola, Florida to represent Panama . Critical reviews of the season were mixed; however, the addition of William Fichtner to the cast was praised. Fox Home Entertainment released the season in Region 1 on September 4, 2007.